The Relationship Between Exercise Frequency, Intensity, and Restoration of Cardiometabolic Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Cardiorespiratory fitness
研究概览
简要总结
Regular physical activity is well established to decrease the risk of cardiometabolic diseases. While research has characterized responses based on exercise intensity, many beneficial effects of exercise are transient in nature, and therefore exercise frequency may play an important, yet currently under-appreciated, role in improving health. The purpose of this study is to determine the efficacy of 6-week high-frequency endurance (END) or low-frequency sprint (SIT) training with respect to reducing clinically relevant cardiometabolic risk factors in overweight/obese males. It is hypothesized that END, performed at a greater frequency than SIT, will markedly improve cardiometabolic health, while low-frequency SIT will not.
详细描述
Involvement in regular physical activity is known to elicit systemic adaptations and reduce the risk of cardiometabolic diseases, including hypertension, obesity, dyslipidemia, and hyperglycemia. Traditional physical activity recommendations suggest that 150 minutes of moderate-intensity continuous endurance (END) exercise dispersed over 5 days per week is sufficient to improve physical fitness in adults. However, given the commonly cited barrier of "lack of time," literature has recently focused on time effective sprint interval training (SIT), obtaining equivalent increases in aerobic capacity and acute glycemic regulation compared to classical END exercise when protocols are work-matched. Despite these similarities, END is conducive to daily sessions not feasible of SIT. As improvements in many clinically relevant risk factors are transient in nature following exercise, it remains imperative to assess the implications of variable frequency exercise regimes performed as per general practice (i.e. high-frequency END, low-frequency SIT). Furthermore, improvements in cardiovascular outcomes following END have been shown, in some instances, to be absent in response to SIT, suggesting END may be more beneficial for cardiovascular health. Therefore, the current study aims to assess several markers of cardiovascular (aerobic capacity, blood pressure, arterial stiffness, vascular endothelial function) and metabolic (glucose tolerance, lipid tolerance, body composition) health following 6-weeks of high-frequency END or low-frequency SIT, performed as per general practice. Combined, this research will provide important insight into the under-appreciated role of exercise frequency for improving cardiometabolic health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Male, aged 18-70 years
- •Body mass index (BMI) > 25 kg/m^2 (classified as overweight or obese)
- •Sedentary (<100 minutes moderate physical activity per week)
- •Approval for vigorous exercise via physical activity readiness questionnaire (PARQ+)
排除标准
- •Prescribed with glucose lowering medications
- •Not cleared for physical activity
结局指标
主要结局
Cardiorespiratory fitness
时间窗: Baseline (pre-training) vs. week 6 (post-training)
Assessed via VO2 peak test, to determine the change in cardiorespiratory fitness following 6-weeks of exercise training
Free-living glycemic regulation
时间窗: Baseline (pre-training) vs. week 6 (post-training)
Assessed via continuous glucose monitoring (CGM), to determine the change in free-living glycemic regulation following 6-weeks of exercise training
Glucose tolerance
时间窗: Baseline (pre-training) vs. week 6 (post-training)
Assessed via an oral glucose tolerance test (OGTT) to determine changes in standardized glycemic regulation following 6-weeks of exercise training
次要结局
- Blood lipids(Baseline (pre-training) vs. week 6 (post-training))
- Arterial stiffness(Baseline (pre-training) vs. week 6 (post-training))
- HbA1C(Baseline (pre-training) vs. week 6 (post-training))
- Arterial stiffness acutely post-exercise(Acutely pre-exercise vs. post-exercise in week 1 of training)
- Brachial artery vascular function(Baseline (pre-training) vs. week 6 (post-training))
- Daily sedentary/active time(Baseline (pre-training), week 1 (of training), week 6 (post-training))
- Free-living glycemic regulation during the first week of exercise training(Baseline (pre-training) vs. week 1 (of training))
- Post-prandial blood lipids(Baseline (pre-training) vs. week 6 (post-training))
- Blood pressure(Baseline (pre-training) vs. week 6 (post-training))
- Body composition(Baseline (pre-training) vs. week 6 (post-training))
- Brachial artery vascular function acutely post-exercise(Acutely pre-exercise vs. post-exercise in week 1 of training)
研究者
Jamie Burr
Dr. Jamie Burr, Director, Human Performance and Health Laboratory, Principal Investigator, Assistant Professor, PhD
University of Guelph