Diagnoses Associated With Persistent Elevation of Creatine Kinase
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 148
- 试验地点
- 1
- 主要终点
- Diagnosis
研究概览
简要总结
Serum creatinine kinase (CK) level varies with age, gender, race and physical activity. For these reasons there is no normal serum CK level. Many pathological situations cause hyperCKemia, such as neuromuscular disorders (muscular dystrophy, inflammatory myositis, mitochondrial myopathy) and multiple systemic causes. The diagnostic approach to pauci or asymtomatic hyperCKemia can therefore be difficult and lead to multiple, and sometimes invasive tests, such as muscle biopsy. This study aims to describe the diagnoses associated with persistent elevation of serum creatine kinase and to precise the role of the muscule biopsy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients hospitalised in a ward of internal medicin
- •having a persistent elevation of serum creatine kinase >3 times the upper normal laboratory value, repeated for 2 times
排除标准
- •known neuro-muscular disease causing elevation of creatine kinase
- •evident post-traumatic cause responsible for the elevation of creatine kinase
- •incomplete medical records
结局指标
主要结局
Diagnosis
时间窗: at the end of all investigations, an average of 12 months
The final diagnosis, as written in the medical record at the end of the investigations in the ward of internal medicin, responsible for the elevation of creatine kinase between: inflammatory myositis, mitochondrial myopathy, muscular dystrophy, non neuromuscular pathology
次要结局
- Muscle biopsy(at the end of all investigations, an average of 12 months)
- Clinical presentation(at the end of all investigations, an average of 12 months)
- Paraclinical presentation(at the end of all investigations, an average of 12 months)
研究者
Lev VOLKOV
Dr
Central Hospital, Nancy, France