Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Renal insult
研究概览
简要总结
comparing the effect of low dose norepinephrine infusion versus fresh frozen plasma in patients undergoing HIPEC to reduce renal insult
详细描述
To compare the efficacy of maintaining intraoperative hemodynamic stability through infusing low dose norepinephrine versus fresh frozen plasma in patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy in cancer patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I and II
- •World Health Performance Status ≤2
- •scheduled for CRS/HIPEC operations
排除标准
- •patient's refusal
- •allergy to any of the used drugs
- •impaired renal or liver functions
研究组 & 干预措施
Fresh frozen plasma
early administration of fresh frozen plasma
干预措施: Fresh frozen plasma (Biological)
Low dose norepinephrine
low dose epinephrine 5 mic/kg/hr
干预措施: Norepinephrine (Drug)
结局指标
主要结局
Renal insult
时间窗: 24 hours
Creatinine level increase 0.3 mg/dl above preoperative baseline
次要结局
未报告次要终点
研究者
Walaa Youssef Elsabeeny
Principal Investigator
National Cancer Institute, Egypt