Carcinogenic Risk of CT in Patients With Appendicitis
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000,000
- 试验地点
- 1
- 主要终点
- Age and sex-standardized incidence rate ratio (IRR) for malignancies of hematologic system
研究概览
简要总结
The purpose of this study is to compare the incidence rate of leukemia between CT-exposed and CT-unexposed group in patients who underwent appendectomy in South Korea.
详细描述
South Korea has a single-payer healthcare system, administered by National Health Insurance Service (NHIS). As healthcare providers in South Korea need to claim reimbursement to NHIS for the vast majority of diagnostic and therapeutic procedures, the NHIS database enabled us to construct a large cohort who did or did not undergo CT for appendicitis. The purpose of this study is to compare the incidence rate of cancer between CT-exposed and CT-unexposed group in patients who underwent appendectomy in South Korea.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients will be entered in the cohort on the date of appendectomy under the diagnosis of appendicitis
排除标准
- •(a) patients who had a cancer diagnosis before the date of appendectomy,
- •(b) those who had prior experience of CT examination more than 7 days before appendectomy,
- •(c) those who had syndromes or diseases predisposing cancers,
- •(d) those whose diagnosis was changed to appendiceal cancer and
- •(e) those whose follow-up duration was shorter than a lag period.
结局指标
主要结局
Age and sex-standardized incidence rate ratio (IRR) for malignancies of hematologic system
时间窗: Cancer occurrence after a lag period (2 years)
Hematologic malignancies are categorized into lymphomas, multiple myeloma, leukemias, myelodysplasia and others using ICD-10 codes.
次要结局
- Age and sex-standardized incidence rate ratio (IRR) for malignancies of abdominal organs(Cancer occurrence after a lag period (2 years))
- Age and sex-standardized incidence rate ratio (IRR) for all cancers(Cancer occurrence after a lag period (2 years))
研究者
Ji Hoon Park
Associated Professor
Seoul National University Bundang Hospital