NCT07598214招募中4 期
Evaluation of the Effect of Diosmin/Hesperidin Combination on Platinum Compounds-Induced Nephropathy in Cancer Patients: A Randomized Controlled Trial
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
研究概览
简要总结
The current study aims to investigate the protective properties of diosmin/hesperidin on cisplatin-induced nephrotoxicity.
详细描述
The current study is a prospective randomized controlled clinical study that will be conducted on about 100 cancer patients.
Study duration The study will be conducted from January 2025 to September 2025
Study population Group I (control): includes 37 cancer patients administrating platinum compounds in their chemotherapeutic cycles as standard therapy.
Group II (Test group) includes 37 cancer patients administrating platinum compounds in their chemotherapeutic cycles as standard therapy plus 450 mg diosmin and 50 mg hesperidin combination orally twice daily.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of 18 to 75 year-age must have histologically or cytologically confirmed cancer by the Laboratory of Pathology receiving a platinum compound chemotherapy.
排除标准
- •-History of allergic reactions attributed to drugs in the study.
- •Pregnant women.
- •Life expectancy less than 6 months
- •Inability or unwillingness to comply with research protocols.
- •Cancer patients with impaired renal function (creatinine clearance < 50 mL/min)
- •Preexisting hearing loss.
- •Patients taking nephrotoxic drugs; and those who have a history of allergic reactions to platinum-containing compounds.
研究者
Hasnaa Osama
lecturer
Beni-Suef University
研究点 (1)
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