The Meniscal Transplant Surgery or Optimised Rehabilitation - Full Randomised Controlled Trial

niversity of Warwick0 个研究点目标入组 144 人开始时间: 2022年9月2日最近更新: 2024年6月18日

适应症

试验速览

2024 Protocol article in https://pubmed.ncbi.nlm.nih.gov/38830746/ (added 04/06/2024)

•1.Pain and/or functional restrictions from the knee, severe enough to warrant potential MAT in the judgement of the treating clinician
•2. Previous meniscectomy more than 6 months ago

•1. Symptomatic ligament instability, not previously corrected, as determined by the assessing clinician
•2. Coronal limb alignment which requires surgical correction, (previous correction, performed at least 6 months before entry to the trial, is not an exclusion criteria), as determined by the assessing clinician
•3. Age under 16 years, or if =16, open growth plate at the proximal tibia as judged by the clinical team on imaging taken as part of standard care
•4. Full thickness cartilage loss (exposed bone) >1 cm2 on routine clinical MRI, prior surgery, or any other form of clinical imaging or evaluation. This will be determined by the assessing clinician (it could be based on an assessment by a clinician or a radiologist, although the final decision rests with the treating clinician)
•5. Inflammatory arthritis affecting the study knee as determined by the assessing clinician (i.e., a prior inflammatory event not considered to be related to the current clinical condition would not require exclusion)
•6. Unable or unwilling to engage with rehabilitation
•7. Unable to adhere to trial processes
•8. Previous randomisation in the present trial (i.e., other knee). Where a previous randomisation has occurred in error, a participant may be withdrawn and this criterion will not apply

发起方

niversity of Warwick