NCT02673632Unknown不适用
The Influence of Anti-Müllerian Hormone on Ovarian Responsiveness to Ovulation Induction With Gonadotrophins in Women With Polycystic Ovarian Syndrome
适应症
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- Good response to hMG therapy defined as occurrence of > 3 mature follicles after treatment.
研究概览
简要总结
The investigator suggests that PCOS women with high AMH levels are resistant to ovarian stimulation and may need adjustment of the dose of gonadotrophin.
详细描述
There is a correlation between high levels of AMH and the severity of PCOS. Excessive AMH may have a negative effect on the sensitivity of the resting follicles to gonadotropins.
This is an observational prospective study to investigate the impact of circulating AMH on gonadotrophin induction in women with PCOS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women of age 18 - 35 years
- •BMI 20 - 30 kg/m2
- •Anovulatory infertility
- •Diagnosis of PCOS based on Rotterdam consensus criteria (two of three criteria: Oligo/anovulation, hyperandrogenaemia and sonographic appearance of polycystic ovaries)
排除标准
- •Women Above 35 years or under 18 years
- •Women with BMI above 30 kg/m2 or under 20 kg/m2
- •Normally ovulating women
- •Patients with marked hyperandrogenaemia were screened for congenital adrenal hyperplasia (by measuring serum concentration of 17alpha hydroxyl-progesterone) or Patients with Cushing syndrome (by measuring urinary free cortisol)
结局指标
主要结局
Good response to hMG therapy defined as occurrence of > 3 mature follicles after treatment.
时间窗: 30 days
Good response to hMG therapy defined as occurrence of \> 3 mature follicles after treatment.
次要结局
未报告次要终点
研究者
Ahmed Mohamed Bahaa Eldin Ahmed
Assistant professor
Ain Shams Maternity Hospital
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