NCT01884142已完成不适用
Effects of Exercise Training on Mechanoreflex and Metaboreflex Control of Muscle Sympathetic Nerve Activity in Heart Failure Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Muscular Evaluation
研究概览
简要总结
The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with systolic heart failure;
- •New York Heart Association (NYHA) class II-III;
- •Left ventricular ejection fraction less than 40%;
- •Peak Oxygen Consumption less than 20 ml/Kg/min;
- •Stable Clinical Status.
排除标准
- •Chronic Obstructive Pulmonary Disease;
- •Neuromuscular Diseases;
- •Orthopedic Diseases;
- •Neurologic Diseases;
- •Neoplastic Diseases;
- •Recent myocardial infarction or cardiac surgery (less than 6 months);
- •Unstable angina pectoris;
- •Atrial Fibrillation;
- •Pacemakers users;
- •Changing medication or hospital admission.
结局指标
主要结局
Muscular Evaluation
时间窗: 4 months
Muscular evaluation will be done by muscle gene expression
Autonomic Control
时间窗: 4 months
Mechanoreceptors were activated by passive exercise and metaboreceptors by post-exercise circulatory arrest
次要结局
- Muscle Blood Flow(4 months)
- Functional Capacity(4 months)
- Blood Pressure(4 months)
研究者
Lígia M. Antunes-Correa
PhD student
University of Sao Paulo General Hospital
研究点 (2)
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