The Effect of Tri-Arm Ayurvedic Intervention on Functional Constipation - A Randomized Clinical Trial

Functional constipation is a prevalent chronic condition among older individuals. The pathophysiology of functional constipation is multifactorial and includes diet, colonic motility as well as absorption, anorectal motor and sensory function, and behavioral as well as psychological factors. It negatively impacts health-related quality of life and economic burdens. After ample research, still patients are dissatisfied with their symptom improvement, adverse effects, and inconvenience. This study of local treatment will help to minimize the dissatisfaction of the patient with present therapies. In the present study, a total of 120 (40 in each group) incidentally enrolled patients with Functional constipation diagnosed with Rome IV criteria will be allotted to any one group among three with a computerized randomization method. This randomized clinical trial aimed to evaluate the efficacy of Bindu ghrita local application on the umbilicus, Trikatvadi varti per rectal administration, and Trivritta churna orally on functional constipation. Patients will be treated for 3 weeks, in the first week with daily medicine, in the second week with alternate-day medicine, and in the third week without medicine in follow-up. Patients who have more than 3 motions/day will be excluded from the study. Patients having constipation for more than 3 days with medicine will be excluded from the study and will be given rescue medicine. Assessment will be done with Rome IV criteria and the question of PAC-QOL. At the end of the trial, data will be collected and subjected to appropriate statistical analysis, and a final conclusion will be framed.