NCT00000348Unknown1 期
Infusion Laboratory: Protocol 4 (Dihydrexidine)
适应症
相关药物
试验速览
- 阶段
- 1 期
- 试验地点
- 2
- 主要终点
- Characterization of study population
研究概览
简要总结
The purpose of this study is to evaluate safety issues pertaining to dihydrexidine (DHX), to cocaine, and to its interaction, and to determine how pretreatment with DHX modifies the subjective as well as physiological effects of cocaine infusion.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •M/F, ages 21-
- •Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent.
排除标准
- •Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.
结局指标
主要结局
Characterization of study population
Degree of drug craving
Frequency of IV drug use and sexual risk behaviors
Type and severity of stimulant withdrawal symptoms
Clinical physiological response to cocaine challen
History, incidence and amount of drug use
Population incidence of symptoms of depression, po
Evidence of change in neurophysiology and brain ac
Evidence of change in subjective responses to coca
Degree to which study medication influences change
次要结局
未报告次要终点
研究者
研究点 (2)
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