Distribution of Topical Nasal Medication Within the Nasal Cavity and Sinuses by Radiographic Comparison
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- To Measure the Distribution of Nasal Sprays and Drops.
研究概览
简要总结
The purpose of this study is to determine the distribution of nasal sprays and nasal drops when used.
详细描述
The purpose of this study is to determine the distribution of nasal sprays and nasal drops when used. The study hypothesizes that nasal drops will reach the frontonasal region more often than nasal sprays.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •adult able to perform activities of daily living
排除标准
- •signs or symptoms of acute or chronic paranasal sinus disease
- •history of sinus surgery
- •symptomatic deviated septum
- •active seasonal allergies
- •allergies to contrast
- •history of nasal polyposis
- •pregnant or breast feeding women
- •neck or back problems that would prevent a subject from kneeling on the floor and crouching over
- •currently taking metformin or amiodarone
- •students or stff under the direct supervision of the investigators
- •cognitive impairment
- •terminal illness
研究组 & 干预措施
Nasal spray
This arm of the study will contain subjects who will spray 2-4 sprays of a nasal contrast solution in their nares. Following administration of the spray, the subjects will then have a Xoran mini-CAT scan of their sinuses.
干预措施: Sinus CT Scan (Radiation)
Nasal spray
This arm of the study will contain subjects who will spray 2-4 sprays of a nasal contrast solution in their nares. Following administration of the spray, the subjects will then have a Xoran mini-CAT scan of their sinuses.
干预措施: Omnipaque 240 Contrast Solution (Drug)
Nasal drop
This arm will contain subjects who will place two drops of a nasal contrast solution in each nose. Following administration of the nasal contrast, the subjects will then have a Xoran miniCAT scan of their sinuses.
干预措施: Sinus CT Scan (Radiation)
Nasal drop
This arm will contain subjects who will place two drops of a nasal contrast solution in each nose. Following administration of the nasal contrast, the subjects will then have a Xoran miniCAT scan of their sinuses.
干预措施: Omnipaque 240 mg I/mL (Drug)
结局指标
主要结局
To Measure the Distribution of Nasal Sprays and Drops.
时间窗: 2 months
CT scan scored for distribution contrast delivered by nasal spray or drops within subsets in the nasal cavity. The sinonasal cavity was divided into twenty-one subsites on each side of the nasal cavity. The interpreters scored for the presence (1) or absence (0) of contrast from the nasal spray or nasal drops within each subsite. Left and right sides were interpreted separately for a possible total score of 0-42 for each CT scan.
次要结局
未报告次要终点