Is Chronic Obstructive Pulmonary Disease a Risk Factor for Cardiovascular Disease?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 162
- 试验地点
- 1
- 主要终点
- Coronary calcium score in cardiac computed tomography
研究概览
简要总结
Patients with chronic obstructive pulmonary disease suffer from significant cardiovascular morbidity and mortality. This study wants to determine whether chronic obstructive pulmonary disease might be a risk factor for coronary atherosclerosis and other cardiac markers independent of conventional cardiovascular risk factors. The study is designed as a retrospective matched case-control study with follow-up via telephone interview.
详细描述
Patients with chronic obstructive pulmonary disease (COPD) suffer from significant cardiovascular morbidity and mortality. Coronary artery disease has often been linked causally to COPD, but the exact pathophysiological mechanisms underpinning this association remain speculative. A retrospective case-control study matching COPD patients and controls one to one for smoking history and conventional cardiovascular risk factors will be performed to study the association between COPD and cardiovascular outcomes. Filling in this knowledge gap may contribute to the understanding of the interplay between COPD and cardiovascular disease.
The objective of this retrospective case-control study is to determine whether COPD might be a risk factor for coronary atherosclerosis, impaired left ventricular ejection fraction, and major adverse cardiovascular events independent of conventional cardiovascular risk factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •SPECT-CT imaging due to preoperative assessment between 01.01.2007 and 31.07.
- •Coronary artery calcium score and left ventricular ejection fraction data available.
- •History of smoking (smoker or ex-smoker).
- •COPD group: Documented chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC < 0.7).
- •Control group: Exclusion of chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC > 0.7).
排除标准
- •Known coronary artery disease or coronary symptoms (angina pectoris) at the time of the SPECT-CT investigation.
- •Known congenital or structural heart disease.
- •Previous heart transplantation.
结局指标
主要结局
Coronary calcium score in cardiac computed tomography
时间窗: Up to one month
Retrospective assessment of SPECT-CT imaging data at the University Hospital Zurich.
次要结局
- Major adverse cardiovascular events(Up to three months)
- Left ventricular ejection fraction in single-photon emission computed tomography(Up to one month)