Epigenetic Regulation of Osteogenesis Imperfecta Severity : miROI Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- micro Ribonucleic Acids (miRs) expression in serum of the patients Osteogenesis imperfecta (OI) type I or III versus control population
研究概览
简要总结
Osteogenesis Imperfecta (OI) is a heterogeneous group of rare connective tissue hereditary diseases responsible for fragility and bone deformity. OI is caused by an autosomal dominant mutation of COL1A1 or COL1A2, encoding α1 and α2 of the collagen, regardless of their phenotypic severity (1 to 5 OI type).
This observation suggests the existence of a undetermined mechanism that may be found in epigenetic regulation, including particularly micro Ribonucleic Acids (miRs).
Indeed, these small non-coding miRs are involved in the regulation of major steps of cellular processes in different pathologies, especially in bone disease.
Currently, no study can provide a satisfactory answer.
This is an etiologic study to reveal the correlation between micro-RNAs (miR) expression and the type I or III of the Osteogenesis Imperfecta (OI).
The aim of this study is therefore to identify miRs significantly associated with the severity of OI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Control population:
- •Male or female
- •18 years old and over
- •Be part of cohorts STRAMBO, OFELY or MODAM
- •Patients with OI:
- •Male or female ≥18 years old
- •Have COL1A1 or COL1A2 mutation
- •Have a diagnosis of type 1 or 3 from Silence classification made by a rheumatologist expert in bone pathologies
排除标准
- •Refusal to participate in the study
- •Have received glucocorticoid treatment for more than 3 months
- •Have received anti-osteoporotic treatment for less than 1 year ago
- •Have Chronic inflammatory rheumatism
- •Have an uncontrolled hypo/hyper thyroidism ou hypo/hyper parathyroidism
- •Have cancer or bone metastases (current or in the past two years)
- •Have benign bone tumors or Paget's disease
- •Have malabsorptive disease (Celiac disease, Whipple's disease, intestinal bypass, short bowel syndrome) and inflammatory bowel disease
- •Pregnant or lactating women
- •Have psychiatric disorders seriously hindering understanding
- •Have difficulties in oral understanding of French language
- •Not a beneficiary of french social security
- •Patients protected by law
研究组 & 干预措施
Osteogenesis imperfecta type 1
Patients with OI type 1
干预措施: Blood sample (Biological)
Osteogenesis imperfecta type 3
Patients with OI type 3
干预措施: Blood sample (Biological)
Control population
The control population corresponds to a pre-existing serum collection of osteoarthritis cohorts (OFELY and MODAM for women, STRAMBO for men).
干预措施: Blood sample (Biological)
结局指标
主要结局
micro Ribonucleic Acids (miRs) expression in serum of the patients Osteogenesis imperfecta (OI) type I or III versus control population
时间窗: up to 1 month (after inclusion)
Identification of specific miRs expressed in the serum of OI patients using NGS (Next Generation Sequencing).
次要结局
- Nature of micro Ribonucleic Acids (miRs) identified by Next-Gen Sequencing (NGS )(Up to 1 month (after inclusion))
- Level of expression of micro Ribonucleic Acids (miRs) identified by Next-Gen Sequencing (NGS )(Up to 1 month (after inclusion))
- Presence of fracture(Up to 1 month (after inclusion))
- Presence of biochemical markers of bone turnover in blood(Up to 1 month (after inclusion))
- Bone pain(Up to 1 month (after inclusion))
- Quality of life(Up to 1 month (after inclusion))
- Assessment of environmental factors(Up to 1 month (after inclusion))