An observational study to estimate the prevalence of mLOX in women with hematological and solid malignancies
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To estimate mosaic loss of X chromosome in women with hematological and solid malignancies
研究概览
简要总结
Mosaic loss of x chromosome of mLOX is the phenomenon that may predict the loss of one copy of a woman’s two x chromosomes with age . The x chromosome inactivation has evolved as a mechanism to compensate for gene dosage imbalances between XX female and XY males , although some genes are only partially inactivated including the tumor suppressor genes(ATRX, KDM5C) . mLOX along with age related types of CH are important pre clinical indicators of hematological cancer risk and identify mitotic mis segregation , autoimmunity , blood cell trait and cancer pre disposition genes as core etiological components for mLOX susceptibility and selection. This study aims to estimate the mosaic loss of x chromosome in women with hematological and solid malignancies , to explore the association between mLOX and age of onset of malignancies and to explore association between mLOX , age of menarche/menopause in different malignancies
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 40.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •All diagnosed patients with multiple myeloma as per IMWG criteria are eligible for inclusion.
排除标准
- •premature ovarian failure turner females known sex chromosome disorders hormone replacement therapy history.
结局指标
主要结局
To estimate mosaic loss of X chromosome in women with hematological and solid malignancies
时间窗: Cross sectional study | Single time point evaluation
次要结局
- to explore association between mLOX & age at onset of malignancies(To explore the association between mLOX age of menarche menopause in different malignancies)