NCT07345858Enrolling By Invitation不适用
Salivary Oxytocin as a Biomarker of Psychedelic Assisted Psychotherapy in Patients With Major Depressive Disorder
University of Geneva, Switzerland1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2026年1月5日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Salivary Oxytocin
研究概览
简要总结
This study aims to investigate whether oxytocin reactivity during a psychedelic session for MDD treatment predicts treatment response, specifically by examining its relationship with changes in flexibility and depressive symptoms.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >=18 years-old
- •MDD defined by DSM-V criteria, and resistant to treatment
- •Ongoing classical psychotherapeutic treatment
- •Agreement to discontinue necessary psychotropic medications (some classes of anti-depressants are allowed with no need to taper off).
排除标准
- •Psychotic or bipolar disorder
- •High suicidal risk
- •Severe cardiovascular, hepatic or neurological (affecting the central nervous system) disorders
- •Pregnancy or breastfeeding.
结局指标
主要结局
Salivary Oxytocin
时间窗: One day
Measure taken during psychedelic treatment
次要结局
- Beck Depression Inventory(3 months)
- Cognitive Flexibility Inventory(3 months)
- Trait anxiety inventory (STAI-T)(3 months)
- Cognitive Emotion Regulation Questionnaire (CERQ)(3 months)
- Emotion Regulation Questionnaire(3 months)
研究者
Tatiana Aboulafia Brakha
PhD
University of Geneva, Switzerland
研究点 (1)
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