Evaluation of the Effect of Exercise on Disease Activity and Immune Parameters in Persons With Rheumatoid Arthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- Tender Joint Count
研究概览
简要总结
This study will evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weightlifting.
详细描述
The goal of this study was to evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis. It was hypothesized that persons would have less inflammation associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weighlifting. Immune parameters were measured to determine potential mechanisms responsible for changes in inflammation with exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •a diagnosis of RA according to the ACR 1989 Criteria at least 6 months prior to enrollment in the study, but not longer than 12 years
- •age 19 to 65 years old
- •stable regimen of medication for 2 months with less than 10 mg/day of oral corticosteroids
- •currently exercise < 2x/week for less than 30 minutes at less than 60% of his/her age predicted maximum heart rate
- •Subjects must pass the Physical Activity Readiness Scale Questionnaire (PAR-Q)
排除标准
- •other serious health problems
- •intra-articular injection within 6 weeks
- •total joint replacement of the large joints
- •use of beta-blockers
- •inability to complete the submaximal exercise test
研究组 & 干预措施
Exercise
Exercise consists of 30 minutes of treadmill exercise at approximately 85% of heart rate max and 2 sets of 6 resistance weight lifting exercises resulting in volitional fatigue at 12 to 15 repetitions.
干预措施: Aerobic and resistance exercise training (Other)
结局指标
主要结局
Tender Joint Count
时间窗: 12 Weeks
Swollen Joint Count
时间窗: 12 Weeks
次要结局
- Estimated Aerobic Capacity (VO2max)(12 weeks)
- Pain (visual Analog Scale)(12 Weeks)
- 50 Foot Walk Test(12 Weeks)
- Patient Global Assessment(12 Weeks)
- Modified-Health Assessment Questionnaire(12 Weeks)
- SF-36(12 Weeks)
- Practitioner Global Assessment(12 Weeks)
- Timed-Stands Test(12 Weeks)