NCT01704053已完成不适用
Monitoring The Anticoagulatory Effects of Dabigatran and Rivaroxaban On Plasmatic and Cellular Coagulation by Rotational Thrombelastometry/-Graphy and Multiple Platelet Function Analyzer
Johann Wolfgang Goethe University Hospital1 个研究点 分布在 1 个国家目标入组 34 人开始时间: 2012年10月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 34
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is determine whether point of care coagulation testing is able to map the anticoagulatory effects of new oral anticoagulants dabigatran and rivaroxaban. Used as devices are thrombelastometry/-graphy (ROTEM, TEG)and multiple platelet function analyzer (Multiplate).
详细描述
Patients receiving dabigatran or rivaroxaban in therapeutic doses are recruited. Blood will be taken twice in correlation to the time of drug intake (before and 3 hours after drug intake). The results of thrombelastometry/-graphy and multiple platelet function analyzer will be compared directly with the concentrations determined by plasma concentration assays.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients receiving Dabigatran or Rivaroxaban
- •Adults > 18 years
排除标准
- •Patients receiving concomittantly inhibitors of platelet function
- •Renal insufficiency (Creatinine > 1,5 mg/dl), Urea > 80 mg/dl)
- •Hemodialysis
- •Hepatic Dysfunction (AST > 30 U/l, ALT > 30 U/l)
研究者
Dr. Matthias Klages
M.D.
Johann Wolfgang Goethe University Hospital
研究点 (1)
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