Study of Low-intensity Focused Ultrasound Effects on Cognitive fMRI Signals
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 80
- 主要终点
- fMRI Signals - Cognition
研究概览
简要总结
Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations. Participants will receive MRI and CT imaging. Participants receive low-intensity focused ultrasound (LIFU) to temporarily change brain activity. Participants then receive fMRI scans to measure changes in both resting and cognitive brain signaling using structured tasks. Heart rate, blood pressure, respiratory rate, and skin moisture is monitored. Participants complete a battery of questionnaires, both behavioral and symptom monitoring. The study takes place over 4 study visits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers, all ethnicities, who understand and speak English.
排除标准
- •Claustrophobia (scanning environment may be uncomfortable).
- •Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
- •Contraindications to CT: pregnancy
- •Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's)
- •History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor)
- •History of head injury resulting in loss of consciousness for >10 minutes.
- •History of alcohol or drug dependence (through self-report).
结局指标
主要结局
fMRI Signals - Cognition
时间窗: Participant study duration, approximately 3 weeks.
Changes in fMRI signals of region of interest during a cognitive task
次要结局
- Executive function task performance(Participant study duration, approximately 3 weeks.)
研究者
Wynn Legon
Assistant Professor
Virginia Polytechnic Institute and State University