NCT02184910Unknown不适用
Usefulness of Serum Pepsinogen and Gastrin as the Predictive Biomarker of Atrophic Gastritis, Intestinal Metaplasia and Gastric Cancer in Korea
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- the change of pepsinogen level before and after H. pylori eradication
研究概览
简要总结
It is well-known that atrophic gastritis is a major risk factor for gastric cancer, which leads to variations in the serum levels of gastrin, pepsinogen (PG) I, and PGII. We want to assess the effects of age, sex, and Helicobacter pylori status on pepsinogen (PG) level for atrophic gastritis and whether gastric atrophy based on the PG test would be improved after H. pylori eradication.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •over 19 years
- •the patients who have gastrointestinal discomfort or get esophagogastroduodenoscopy (EGD) for health check up
- •the patients who got the procedure, endoscopic submucosal resection (ESD) for early gastric cancer
排除标准
- •gastrectomy history
- •advanced gastric cancer (impossible to get the gastrectomy)
- •Helicobacter eradication history
- •the patients who have chronic disease
- •cancer patients except gastric cancer within 6 months
- •who cannot perform this study according to research's decision
- •who have bleeding tendency (ex. taking antiplatelet agent, low platelet count or abnormal coagulation time)
研究组 & 干预措施
gastritis and pepsinogen
干预措施: pepsinogen and gastrin (Drug)
结局指标
主要结局
the change of pepsinogen level before and after H. pylori eradication
时间窗: baseline and 6 months
to compare the change of the pepsinogen level before and after H. pylori eradication and evaluate the correlation between the pepsinogen level and the atrophic gastritis
次要结局
未报告次要终点
研究者
研究点 (1)
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