NCT05839028进行中（未招募）不适用
Mechanisms of Left Ventricular Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Conditions of the Arctic Region
Tomsk National Research Medical Center of the Russian Academy of Sciences2 个研究点 分布在 2 个国家目标入组 550 人开始时间: 2022年10月16日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 550
- 试验地点
- 2
- 主要终点
- Echocardiographic assessment of GLS (Global longitudinal strain), %
研究概览
简要总结
The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.
详细描述
Hypothesis
In patients with hypertension working in the conditions of the Arctic shift, the combination of climatic and geographical factors and rotational expeditionary method of labor contributes to the increase in the left ventricular remodeling processes and leads to the formation of heart failure with preserved ejection fraction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The patient signed the informed consent
排除标准
- •Valvular pathology of the heart
- •Past cardiac or cerebral complications
- •Identified heart rhythm disturbances
- •Coronary heart disease
- •Patients with severe somatic pathology, whose prognostic survival rate does not exceed 1 year
- •The presence of a mental disorder of organic origin
结局指标
主要结局
Echocardiographic assessment of GLS (Global longitudinal strain), %
时间窗: One year
Echocardiographic assessment of global strain (%) at baseline and after one year of follow-up.
次要结局
- Concentration of oxidized low density lipoproteins, CU(One year)
- Concentration of homocysteine, umol/L(One year)
- Concentration of C-reactive protein, IU/L(One year)
- Concentration of 1,6,8 interleukins, pg/mL(One year)
- Concentration of GDF-15/MIC-1 (Growth Differentiation Factor 15/Macrophage-inhibitory 1), pg/mL(One year)
- Concentration of testosterone, nmol/L(One year)
- Concentration of Myeloperoxidase, ug/mL(One year)
- Concentration of noradrenaline, pg/mL(One year)
- Concentration of FGF-23 (Fibroblast growth factor 23), pmol/L(One year)
- Concentration of tumor necrosis factor alpha, pg/ml(One year)
- Concentration of PIIINP (N-terminal propeptide to procollagen III), ng/mL(One year)
- Concentration of plasma procollagen type 3, CU(One year)
- Concentration of progesterone, nmol/L(One year)
- Concentration of adrenaline, pg/mL(One year)
- Concentration of estradiol, pg/mL(One year)
- Concentration of cystatin-C, ng/mL(One year)
- Concentration of NGAL (Neutrophilic gelatinase-associated lipocalin or neutrophilic lipocalin), ng/mL(One year)
研究者
研究点 (2)
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