Identification of neutralizing antibodies against severe or chronic infections of human being - INA

niversitätsklinikum Köln0 个研究点目标入组 1,000 人开始时间: 2016年4月13日最近更新: 2024年8月19日

试验速览

暂无简介。

•Patients suffering from chronic infections or passing trough severe infections within the last 10 years or healthy people as volunteers, and Karnofsky > 80

•-Leukopenia < 2.000 Leukocytes/µl
•-Hb < 10 g/dl
•-Platelets < 50.000 Plateelts/µl
•-Known acquired or hereditary coagulation disorder, including anticoaguant treatment
•-CHF NYHA II-IV
•-COPD GOLD Stadium III-IV
•-History of myocardial infarcation or current symptomatic coronary artery disease
•-Symptomatic cardiac or pulmonary disease
•-Body weight below 45 kg (for an apheresis or blood draw of > 250 mL, a body weight of 50 kg is required)
•-< 8 (men) or 12 (women) weeks since last blood donation or blood draw volume of > 100 mL
•-Within 1 week after small surgery (biopsy, tooth extraction), or within 1 month after larger surgery (e.g., thoracotomoy, open abdominal surgery) or surgery with high risk of postoperative bleeding (e.g., tonsillectomy)
•-Acute or unknown health deterioration
•-Participation in another interventional study
•If a leukapheresis is planned, the following additional exclusion criteria apply:
•-History of significant complication from leukapheresis or citrate-based anticoagulation
•-INR > 1.5 or aPTT > 60 s
•-Premenopausal women that cannot rule out pregnancy at the time of apheresis

发起方

niversitätsklinikum Köln