Stable Isotope Biomarker for Added Sugar Intake and Sweet Taste Phenotypes in Mother-child Dyads
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 277
- 试验地点
- 1
- 主要终点
- Diet intake
研究概览
简要总结
The goals of this cross-sectional study on a racially diverse group of children (3-10y) and their mothers are to determine whether the relationship between sweet taste phenotypes differed among mother-daughter and mother-son dyads and to determine the predictive value of a hair biomarker (delta13C). Given the widespread overconsumption of added sugars, and the associated burden of disease, improving surveillance measures and developing strategies to reduce added sugar intake, especially among the youngest members of society, are public health priorities.
详细描述
This is a single-site cross-sectional study designed to investigate the relationship of sweet taste phenotypes among mother-child dyads and assess the predictive value of a hair biomarker for sweet taste phenotypes. For each participant, we will collect 2-day 24-hour dietary recalls to determine added sugar intake; directly assess the level of sweet taste most preferred; measure liking/disliking of sweet tasting foods and beverages; collect anthropometric measures; and collect at least 3 cm of hair for biomarker analyses. Mothers will also complete a variety of questionnaires on parenting and child behavior.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 3 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Hair that is greater than or equal to 3 cm in length
- •Child is between the ages of 3 and 10 years and adult is between the ages of 18 and 70
- •Access to electronic device including Smartphone, iPad, tablet, laptop, or desktop computer for participation in remote study visits.
排除标准
- •Diagnosis of Type 2 Diabetes
结局指标
主要结局
Diet intake
时间窗: Through study completion, average 2 and a half years
Two days of dietary intake will be obtained by having mothers report all the foods and beverage eaten during past day using the Automated Self-Administered Recall System (ASA24). Mothers will complete for herself and her child on two separate days. From these data, we will obtain daily energy intake (kcal/d), sugar (g/d; kcal/d) intake
PALS/ALS Liking surveys
时间窗: Through study completion, average 2 and a half years
Liking of different types of foods will by assessed by Preschool Adapted Liking Survey (PALS) for children \[range -100 (maximal dislike) to 100 (maximal like)\] and the Adult Liking Survey (ALS) for adults \[range -100 (maximal dislike) to 100 (maximal like)\]
Hair Biomarker for added sugar intake
时间窗: After study completion, 2022
Three cm of each hair sample will undergo stable isotope ratio mass spectrometry that will yield the concentration of carbon-13 relative to carbon-12 (added sugar biomarker, which has been shown to be associated with added sugar intake in older children and adults. Each cm reflects the added sugar intake of one month.
Sweet taste preferences
时间窗: Through study completion, average 2 and a half years
Level of sucrose most preferred as determined by the Monell forced-choice tracking method \[range of sucrose solutions: 0.09 to 1.05 M\]
次要结局
- Eating Behavior constructs(Through study completion, average 2 and a half years)
- Anthropometry(Through study completion, average 2 and a half years)
- Waist-to-Hip ratio(Through study completion, average 2 and a half years)