A Randomised Control Trial to Assess Efficacy of Preoperative High Intensity Interval Training in Elderly Patients Scheduled for Oncological Abdominal Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- VO2AT (VO2 at anaerobic threshold)
研究概览
简要总结
This randomized control trial will determine the effect of short term high intensity interval training (HIIT) on physical fitness, in an elderly patient group with active cancer, prior to surgical resection.
Half of the recruited patients will act as a control group and the other half will undergo a HIIT protocol.
详细描述
High intensity interval training (HIIT) has been shown to achieve similar and in some studies better improvements in aerobic fitness versus more traditional endurance based exercise over the same time period. HIIT has also been shown to produce these improvements over a shorter timescale than other methods, in the region of 2-6 weeks. One widely reported barrier to exercise is time availability, HIIT training may be a favorable option to increase fitness as the total time spent exercising is significantly less than other methods. HIIT induces improvements in cardiovascular parameters in healthy elderly subjects, investigators aim to investigate whether these improvements can be matched in patients with cancer and further elucidate the mechanisms behind improvements seen with this type of training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged over 65 years (no upper age limit).
- •Histologically proven, radiologically or direct visualisation leading to high clinical suspicion of cancer.
- •Sufficient mobility to be able to exercise on a static exercise bike.
- •Ability to give informed consent.
- •Ability to travel to RDH to complete the HIIT sessions (may also rely upon dependents/relatives to provide transport).
排除标准
- •Adjuvant systemic chemotherapy / radiotherapy treatment for this cancer. Participants with a significant past medical history of:
- •Myocardial infarction (within last 6 months)
- •Unstable Angina
- •Heart failure (NYHA class III/IV)
- •Uncontrolled Hypertension (BP>160/100)
- •Previous stroke/TIA
- •Severe respiratory disease inc. known pulmonary hypertension(>25 mmHg), Forced Expiratory Volume in 1 second <1.5l.
- •Brittle asthma / exercise induced asthma
- •Known cerebral aneurysm.
- •Inclusion in a recent (within 3 months) study which included any form of exercise, taking a drug or ionising radiation.
研究组 & 干预措施
Control
Control: This group of patients will receive 'current best practice' as per UK NHS recommendations for their specific cancer management prior to surgery.
High intensity interval training
Exercise: Participants in this group will attend 3-4 times per week to complete HIIT training during the period from diagnosis to surgery.
High intensity interval training (HIIT)
干预措施: High intensity interval training (HIIT) (Other)
结局指标
主要结局
VO2AT (VO2 at anaerobic threshold)
时间窗: Baseline and 4 weeks
Change in anaerobic threshold seen during maximal exercise test (pre and post intervention).
次要结局
- Subjective acceptability of HIIT preoperatively (via questionnaire)(After 4 weeks of HIIT.)
- Muscle protein synthesis rate changes with HIIT.(Baseline and 4 weeks.)
- VO2peak(Baseline and 4 weeks)