Prospective Athlete's Heart Study: Long-term Assessment of the Determinants of Cardiac Remodelling and Its Clinical Consequences in Endurance Athletes
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 450
- 试验地点
- 4
- 主要终点
- Genotype
研究概览
简要总结
The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e. accurately evaluated in term of type, frequency, duration and intensity) and genotype on the variability of structural, functional and electrical exercise induced cardiac remodeling (EICR) in young competitive endurance athletes. The second objective is to determine how EICR, training load and genotype are associated with physical performance, health benefits and cardiac pathology (e.g. exercise-related cardiomyopathies and arrhythmias) during follow-up over several decades.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 14 Years 至 23 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and females aged 14-23 years old
- •Athletes competing in endurance sports at national or international level for at least 2 years. Sports include:
- •Distance running (≥ 1500 meters)
- •Non athletes engaged in < 3 hours per week of physical activity
排除标准
- •Medical history of cardiovascular disease
- •Current smoker of past history of smoking
- •Diabetes mellitus
结局指标
主要结局
Genotype
时间窗: Baseline
Rare and common variants in cardiomyopathy associated genes
Atrial fibrillation
时间窗: Baseline to 20 years
Ventricular arrhythmias
时间窗: Baseline to 20 years
Ventricular ectopic beats, non-sustained and sustained ventricular tachycardia
Training load
时间窗: Baseline to 20 years
Duration and intensity of training
次要结局
未报告次要终点
研究者
dr. Guido Claessen
Chair
Universitaire Ziekenhuizen KU Leuven