Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma: An Immunohistochemical Study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 主要终点
- Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma
研究概览
简要总结
Vitamin D has a crucial role in cancer control and prevention.vitamin D receptor (VDR) and its heterodimer Retinoid X receptor (RXR) are equally important in the cell. This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell.
Retinoid receptors are a superfamily of nuclear receptors. The preferred receptor that attaches to VDR is RXR, with its subunits α, β and γ. RXR α is more frequent in the skin than other tissues, while β occurs in internal organs and γ is frequently related to neural disorders.
the investigator hopes to assess prognosis of SCC & BCC by using RXR-α biomarker & attempts to use it in the treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Squamous cell carcinoma and basal cell carcinoma.
- •Incisional & excisional biopsies.
- •All the studied cases include sufficient materials for the immunohistochemical study
- •Complete clinical data
排除标准
- •Patients with a history of preoperative chemotherapy and/or radiotherapy.
- •Insufficient or tiny tissue biopsies.
结局指标
主要结局
Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma
时间窗: One or two days after staining sections with the marker.
immuohistochemical expression of RXR-α in Squamous and Basal Cell Carcinoma
次要结局
未报告次要终点
研究者
Fatma Mohammed Hamdan
demonstrator at pathology department
Sohag University