Predicting Response to Azithromycin Therapy in Asthma - Azithromycin in Asthma

niversity of Nottingham0 个研究点目标入组 10 人开始时间: 2011年3月30日最近更新: 2019年6月30日

适应症

试验速览

暂无简介。

•Male or Female aged between 18-80 years old
•Clinical diagnosis of refractory Asthma
•Symptomatic despite receiving treatment at step 4 of the BTS asthma guidelines: evidence of poor asthma control in terms of regular night-time awakening (>2/week) or more than 4 puffs of relief medication/day (>twice/week) requiring repeated (2 or more per year) courses of oral corticosteroids despite treatment with high dose inhaled corticosteroids (=1000mg beclomethasone or equivalent) and treatment with, or a previous unsuccessful trial of, a long-acting beta-agonist or leukotriene antagonist.
•Male or Female aged between 18-80 years old
•Never Smoker
•No Respiratory Disease
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•Pregnant Females
•Inadequate Contraception or Lactation
•Antibiotic course within the last 6 weeks
•Smoking history in excess of 20 pack years
•Clinical diagnosis of ABPA
•Bronchiectasis
•Abnormal liver function tests
•History of liver disease
•Medication known to interact with azithromycin (e.g. ciclosporin, digoxin, ergot derivatives, terfenadine, warfarin, antacids, and ritonavir)
•Pregnant females
•Antibiotic course within the last 6 weeks
•Abnormal liver function tests

发起方

niversity of Nottingham