Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy
研究概览
简要总结
The purpose of this study is to detecte and predict early subclinical cardiac damage induced by thoracic radiation therapy based on two-dimensional speckle tracking echocardiography combined with multiple circulating biomarkers.
详细描述
This is a monocentric prospective cohort study in which 100 patients treated for malignant tumors and with cardiac radiation exposure will be included.All patient will be followed for 12 months after radiotherapy. Echocardiography, 2D STE parameters and circulating biomarkers will be collected.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •with malignant tumors
- •will receive radiotherapy
- •with cardiac exposure during the radiotherapy process
- •could receive regular follow-up for 12 months
- •written informed consent
排除标准
- •satisfactory echocardiographic images could not be obtained
- •moderate or severe valvular disease
- •cardiomyopathy
- •congenital heart disease
- •refractory hypertension
- •coronary artery disease*
- •heart failure
- •arrhythmia requiring intervention
- •pericarditis
- •acute myocarditis
- •participating in other clinical studies of drug intervention
- •severe liver and kidney dysfunction
- •autoimmune disease
- •pulmonary hypertension
- •coronary artery disease: at least 50% stenosis besed on previous coronary angiography or CTA, or with a history of percutaneous coronary stent implantation.
- •*: with LVEF<50%, unstable angina，or acute myocardial infarction within 3 months.
结局指标
主要结局
Early Detection of Cardiac Damage by Two-Dimensional Speckle Tracking Echocardiography After Thoracic Radiation Therapy
时间窗: 2020-2021
To detecte early subclinical cardiac damage induced by thoracic radiation therapy, based on two-dimensional speckle tracking echocardiography combined with multiple circulating biomarkers
次要结局
未报告次要终点