NCT02622854已完成不适用
Comparison of Plasma Exchange and Conservative Management in Non-severe Acute Hypertriglyceridemic Pancreatitis With Mildly Elevated Triglycerides
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- decrease in triglycerides
研究概览
简要总结
To compare effectiveness in reducing triglycerides between daily plasma exchange and glucose+insulin infusion in patients with non-severe acute hypertriglyceridemic pancreatitis with mildly elevated triglycerides
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •mild acute hypertriglyceridemic pancreatitis
- •triglycerides >15 but < 40 mmol/l
排除标准
- •pregnancy
- •severe course of pancreatitis
研究组 & 干预措施
plasma exchange
Experimental
plasma exchange, with 1.5 estimated plasma volume exchanged with albumin solution, using citrate anticoagulation, performed daily until triglycerides <=10 mmol/l
干预措施: plasma exchange (Procedure)
conservative treatment
Active Comparator
infusion of 5% glucose and insulin, to maintain blood glucose at 5-8 mmol/l
干预措施: conservative treatment (Drug)
结局指标
主要结局
decrease in triglycerides
时间窗: within first 24 h after admission
as % of starting value
次要结局
- time until triglycerides drop to <10 mmol/l(by the end of hospital stay, up to 100 days)
- highest C-reactive protein (CRP)(by the end of hospital stay, up to 100 days)
- % of patients with severe pancreatitis(by the end of hospital stay, up to 100 days)
研究者
Jakob Gubensek
MD, PhD
University Medical Centre Ljubljana
研究点 (1)
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