Neurophysiological Evaluation of Training Effect on Cancer-Related Weakness
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 试验地点
- 4
- 主要终点
- Hand grip force
研究概览
简要总结
Breast cancer patients often suffer from long-term physical symptoms of weakness. In this study, investigators propose to compare how two different low intensity physical exercise training programs can improve handgrip strength for breast cancer patients with symptoms of weakness. Using brain imaging, the study will also investigate changes in brain structure, and muscle activity associated with handgrip.
详细描述
Participants will be randomized to either a no treatment group or one of two low intensity 6-week exercise training. Outcomes will be measured at baseline, post-intervention and 4 weeks post intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female aged 40-75 yrs
- •Right handed, as determined by the Edinburgh Inventory (Oldfield, 1971)
- •Proficient in English
- •Must be available for the familiarization, and testing sessions
排除标准
- •Symptoms for mild or severe depression as determined by a Patient Health Questionnaire (PHQ-8) score >14
- •Significant cognitive impairments as defined by a score <28 in the Folstein Mini-Mental Screening Examination (MMSE, Folstein et al .1975).
- •Participated in any type of motor imagery or strength training program in the last 5 years, or plan to start any motor imagery or physical strength training program for the 3 months duration of the study
- •Neurological, psychiatric, musculoskeletal or other types of disorder that may affect participants sensorimotor function and cognitive abilities
- •Current medication believed to affect cognitive/psychomotor function (i.e., opioid, analgesics, anxiolytics or antidepressants)
- •History of alcohol, smoking, and drug abuse
- •Any contraindication for MRI
结局指标
主要结局
Hand grip force
时间窗: Pretest (before training), Posttest (immediately after end of training), Retention test (4 weeks after end of training)
Primary outcome will be used to compare pre to post change in maximum force contraction at the end of the 6-week intervention between groups.Similar comparison will be done between retention test (4 weeks after training) and posttest (immediately after training).
次要结局
- Functional brain to muscle (EEG-EMG) phase coupling at low intensity handgrip muscle contraction.(Pretest (before training), Posttest (immediately after end of training), Retention test (4 weeks after end of training))
- functional brain to muscle coupling during fatigue(Pretest (before training), Posttest (immediately after end of training), Retention test (4 weeks after end of training))
- Pre to Post changes in EMG amplitude at maximum handgrip contraction(Pretest (before training), Posttest (immediately after end of training), Retention test (4 weeks after end of training))
- EEG Brain connectivity during low intensity handgrip muscle contraction(Pretest (before training), Posttest (immediately after end of training))
- Fatigue sustained handgrip contraction task duration(Pretest (before training), Posttest (immediately after end of training), Retention test (4 weeks after end of training))
- Pre to Post changes of functional brain to muscle coupling at maximum handgrip contraction(Pretest (before training), Posttest (immediately after end of training), Retention test (4 weeks after end of training))
- Pre to Post changes in Brain activity during maximum handgrip contraction(Pretest (before training), Posttest (immediately after end of training))