NCT06337227招募中不适用
Potential Role of Sirtuins As Epigenetic Biomarkers for the Clinical Management of the Patient with Atherosclerosis or Calcific Aortic Stenosis
IRCCS SYNLAB SDN1 个研究点 分布在 1 个国家目标入组 3 人开始时间: 2023年10月19日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 3
- 试验地点
- 1
- 主要终点
- To evaluate by analysis of data obtained from NGS techniques whether and which proteins belonging to the Sirtuin family may be deregulated in patients with atherosclerosis or calcific aortic stenosis
研究概览
简要总结
The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with atherosclerosis or calcific aortic stenosis with and without diabetes older than 18 years of either sex;
- •Patients without atherosclerosis undergoing surgical procedure for endocarditis;
- •Patients who will have signed informed consent
排除标准
- •Patients for whom biological material cannot be recovered for study purposes;
- •Patients who refuse to participate in the study
结局指标
主要结局
To evaluate by analysis of data obtained from NGS techniques whether and which proteins belonging to the Sirtuin family may be deregulated in patients with atherosclerosis or calcific aortic stenosis
时间窗: 36 months
次要结局
- To evaluate the experimental results achieved in the clinical-diagnostic context(36 months)
研究者
研究点 (1)
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