The Neutrophil-to-lymphocyte Ratio (NLR) and Platelet-to-lymphocyte Ratio (PLR) Levels Following IPACK Block in Knee Arthroplasty: a Randomized, Controlled Trial.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Neutrophil-to-lymphocyte ratio
研究概览
简要总结
Effect of iPACK block on NLR and PLR following knee arthroplasty
详细描述
The NLR is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value. NLR is a cheap, simple, fast-acting, readily available stress and inflammation parameter with high sensitivity and low specificity. Dynamic changes in the NLR precede the clinical state for several hours and may alert clinicians early about the ongoing pathological process. NLR is a new promising marker of cellular immune activation, an important indicator of stress and systemic inflammation. It opens a new dimension for clinical medicine to understand better the biology of inflammation, the linkage, and antagonism between innate and adaptive immunity, and its clinical consequences for health and disease.
NLR is affected not only by surgical trauma but also by the method of anesthesia. In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. However, there have been very few studies evaluating the effect of various methods of anesthesia on the NLR.
This is the first study to investigate the effect of regional anesthesia on the NLR and PLR in patients undergoing knee replacement surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with ASA classification I-III
- •Aged 20-90 years
- •Who will be scheduled for hip arthroplasty under spinal anesthesia
排除标准
- •Patients who have a history of bleeding diathesis
- •Take anticoagulant therapy
- •History of chronic pain before surgery
- •Multiple trauma
- •patients unable to assess their pain (dementia)
- •patients operated under general anesthesia
- •patients having an infection in region of the procedure
- •patient who do not accept the procedure
研究组 & 干预措施
Sham blocks
iPACK block with 20ml of 0.9% sodium chloride
干预措施: 0.9% Sodium Chloride Injection (Drug)
iPACK block
iPACK block with 20ml 0f 0.2% ropivacaine
干预措施: Ropivacaine 0.2% Injectable Solution (Drug)
结局指标
主要结局
Neutrophil-to-lymphocyte ratio
时间窗: 12 hours after surgery
Neutrophil to lymphocyte ratio (NLR) is used as a marker of subclinical inflammation. It is calculated by dividing the number of neutrophils by number of lymphocytes, usually from peripheral blood sample, but sometimes also from cells that infiltrate tissue, such as tumor.
次要结局
- PLR(48 hours after surgery)
- NLR(48 hours after surgery)
- first need of opiate(48 hours after procedure)
- Opioid Consumption(48 hours after surgery)
- Pain score(48 hours after surgery)