Noninvasive Electrocardiographic Imaging for Individuals at Risk for Apparently Idiopathic Ventricular Fibrillation.
试验速览
- 阶段
- 不适用
- 入组人数
- 500
- 试验地点
- 3
- 主要终点
- ECG-Imaging outcome: epicardial potentials
研究概览
简要总结
This study aims to evaluate the electrophysiological properties of the heart conduction system in patients with unexplained polymorphic ventricular tachycardia (VT) and/or ventricular fibrillation (VF), in patients with specific genetic mutations regarding sudden cardiac death or sudden cardiac arrest, in their family members and in a control cohort. The electrophysiological properties will be measured with the relatively new technique ECG-Imaging (ECGI).
Also a National Dutch registry for patients with unexplained polymorphic VT and/or VF and their family members will be created.
By combining the data from the registry and the results of ECGI, The investigators hope to identity risk markers for patients at higher risk for apparently idiopathic ventricular fibrillation, and use these for an adapted flow chart for the 'general'population of patients at risk for unexplained polymorphic VT and/or VF. The investigators aim to be able to identify patients before the first arrhythmic event, and aim for better treatment strategies in the future.
详细描述
ECGI combines electrical body-surface mapping with 256 electrodes placed on the thorax with a CT-scan obtaining the anatomy of the heart and torso, hereby able to reconstruct local electrograms, activation and recovery times. In recent research, ECGI provided numerous extra insights into normal cardiac electrophysiology, but also electrophysiological disorders and disease. The results strongly suggest that ECGI can play a pivotal role in further characterizing arrhythmia mechanisms, therefore could do so for polymorphic VT or idiopathic VF leading to diagnosis and treatment improvement. Moreover, ECGI seems to have the potential to detect arrhythmogenic substrate in individuals before their first event, offering the possibility to diagnose and treat patients before sudden cardiac arrest occurs.
In the VIGILANCE study:
- ECGI will be used to noninvasively characterize the epicardial electrophysiological substrate and triggers of:
- Patients with unexplained polymorphic VT and VF,
- Index patients of family cohorts with a specific genetic mutation related to arrhythmogenesis, at high risk for unexplained polymorphic VT and/or VF.
- Family members,
- A control cohort. Results will be evaluated for risk stratification.
- All unexplained polymorphic VT and/or VF patients and their family members will be asked to participate in a National Dutch registry, and these date will be analysed to determine their prognostic value in terms of arrhythmia risk
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •In order to be eligible to participate in this study, a subject must be ≥ 18 years old and meet one of the following criteria:
- •All unexplained polymorphic VT or VF survivors in whom known structural myocardial, respiratory, metabolic and toxicological causes have been excluded through clinical evaluation", with/without a genetic mutation. NB. If results of a diagnostic tests show minor abnormalities but insufficient for a specific diagnosis, this is no exclusion criterion.
- •Selected family members of these patients*
- •Control subjects with structurally normal hearts with a clinical indication for a cardiac CT scan.
- •All 1st and 2nd degree family members being in contact with the cardiologist/treating physician as part of cascade screening will be contacted as described in chapter 11.2.
- •Family members must be in adequate health to be able to travel to the hospital for research purposes.
- •3rd degree family members can also be contacted as described in chapter 11.2.2 if at least one of the following criteria is met:
- •The family member has the same genetic mutation as index patient, or;
- •The family member has demonstrated ventricular arrhythmias, or;
- •The clinician has a very strong suspicion of ventricular arrhythmias in the family member.
排除标准
- •A potential subject who meets any of the following criteria will be excluded from participation in this study:
- •A known strong reaction against electrode attachment or contrast agent.
- •Any serious medical condition, which in the opinion of the investigator, may adversely affect the safety and/or effectiveness of the participant or the study.
- •Pregnancy, nursing or planning to be pregnant.
- •Subject has an estimated glomerular filtration rate (eGFR) of <30mL/min/1.73m2
- •, using the MDRD calculation
- •Unability to give informed consent.
- •Family members of patients with unexplained polymorphic VT/VF, who have severe cardiac abnormalities and/or disease not related to the symptoms or phenotype of the index patient, and which may have a negative influence on results of ECGI according to local investigators.
结局指标
主要结局
ECG-Imaging outcome: epicardial potentials
时间窗: 3 years
reconstructed epicardial potentials, represented in mV over time(s).
ECG-Imaging outcome: activation and repolarization maps
时间窗: 3 years
Activation and repolarization maps. These are made by measuring acivation and repolarization times from the reconstructed potentials in miliseconds. Then local activation and recovery times are plotted on a CT-derived heart mesh. The entire activation and repolarization of the epicardium of the heart can be visualized this way.
次要结局
- (Possible) Prognostic risk factors for recurrent ventricular arrhythmias(3 years)
- Recurrence of ventricular arrhythmias(3 years)