Fear Potentiation and Fear Inhibition in Posttraumatic Stress Disorder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 425
- 试验地点
- 2
- 主要终点
- Fear potentiation of acoustic startle
研究概览
简要总结
The current study will investigate the ability of people with and without fear symptoms after trauma to inhibit fear in an experimental situation.
详细描述
Title of addendum: fear potentiation, conditional discrimination, and fear inhibition in posttraumatic stress disorder.
Principal Investigator: Erica Duncan, M.D.
Co-Investigator: Seth Norrholm, M.D.
Background:
Fear potentiation of the acoustic startle response (ASR) can be demonstrated in both animals and humans (Davis et al., 1993; Grillon et al., 1991). The neural correlates of fear potentiated startle are well studied (Davis et al., 1993) and this paradigm has face validity with cardinal symptoms of posttraumatic stress disorder (PTSD). Central to the clinical problem of PTSD is the inability of these patients to inhibit their fear to stimuli reminiscent of their traumatic experience, even during safe conditions. The elucidation of mechanisms of fear inhibition that may be abnormal in these patients has the potential to advance the development of effective treatments for these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-80
- •Diagnosis of PTSD
- •Healthy controls (no history of PTSD)
- •Combat controls (no history of PTSD)
排除标准
- •No drug or alcohol abuse or dependence
研究组 & 干预措施
1
Subjects with posttraumatic stress disorder
干预措施: Acoustic Startle Testing (Behavioral)
2
Healthy controls
干预措施: Acoustic Startle Testing (Behavioral)
3
Combat controls
干预措施: Acoustic Startle Testing (Behavioral)
结局指标
主要结局
Fear potentiation of acoustic startle
时间窗: Baseline
Percent change in acoustic startle magnitude during visual cue conditioned to aversive stimuli, compared to trials without aversive stimuli
次要结局
未报告次要终点
研究者
Erica Duncan, MD
Professor
Emory University