Effect of Multicomponent Exercise on Cognitive Function and Activities of Daily Living in People With Dementia
试验速览
- 阶段
- 不适用
- 入组人数
- 52
- 主要终点
- Mini-Mental State Examination
研究概览
简要总结
People with dementia shows a decline in cognition, such as memory, executive function (EF), language, attention, and spatial orientation that is significant enough to interfere with the independence and daily functioning. Previous studies reported that multicomponent exercise improved EF in people with mild cognitive impairment and independence of ADL in those with Alzheimer's disease. However, few studies investigated whether multicomponent exercise improved EF, memory, and ADL in people with dementia. Therefore, the purposes of this study are to examine 1) the effect of multicomponent exercise on EF, memory, and ADL in people with mild to moderate dementia; 2) the correlation between change in EF and ADL; 3) the correlation between change in memory and ADL.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 60-80 y/o
- •Mini-Mental State Examination: 10-26
- •Clinical Dementia Rating: 1-2
- •Walk at least 6 meters independently (with or without walking aids)
排除标准
- •Any other diagnosis of neurological diseases or musculoskeletal problems (Except dementia)
- •Physical or psychological comorbidities that affect performance during assessment or intervention
- •Already participating in other physical training in the last 1 month
研究组 & 干预措施
Multicomponent exercise group
干预措施: Multicomponent exercise (Other)
Video home exercise group
干预措施: Video home exercise group (Other)
结局指标
主要结局
Mini-Mental State Examination
时间窗: Change from baseline at 9 week
It is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment. Higher scores mean a better outcome.
Trail making test - Chinese version
时间窗: Change from baseline at 9 week
It is a measurement to evaluate cognitive flexibility.
Chinese version of Stroop color and word test
时间窗: Change from baseline at 9 week
It is a measurement to evaluate inhibition control.
Digit span test
时间窗: Change from baseline at 9 week
It is a measurement to evaluate working memory.
Chinese version of Verbal learning test
时间窗: Change from baseline at 9 week
It is a 9-point measurement to evaluate memory. Higher scores mean a better outcome.
次要结局
- Berg Balance Scale(Change from baseline at 9 week)
- Time up and go test(Change from baseline at 9 week)
- 30-second chair stand test(Change from baseline at 9 week)
- Chinese version of Quality of Life in Alzheimer Disease Scale(Change from baseline at 9 week)
- 6-minute walk test(Change from baseline at 9 week)
- Barthel index(Change from baseline at 9 week)
- Instrumental activities of daily living (IADL) scale(Change from baseline at 9 week)
研究者
Yea-Ru Yang
Professor
National Yang Ming Chiao Tung University