NCT02827357已完成不适用
Review of Responses to Systemic Chemotherapy of Patients With Non-small Cell Lung Cancer Harboring a Known Somatic Activating HER2 Mutation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 101
- 主要终点
- Overall response rate
研究概览
简要总结
This chart review describe the response to systemic chemotherapy of patients with non-small cell lung cancer (NSCLC) harbouring a known somatic activating human epidermal growth factor receptor 2 (HER2) mutation. The analysis of this data will provide an initial description of the response to systemic chemotherapy in patients with NSCLC harboring an activating HER2 mutation in order to inform the design and powering of future randomized controlled clinical trials of HER2-directed therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with advanced nonsmall-cell lung cancer
- •known HER2 exon-20 insertion
- •treated with chemotherapy and/or HER2-targeted drugs
排除标准
- 未提供
结局指标
主要结局
Overall response rate
时间窗: 24 months
次要结局
- Median progression-free survival (PFS) with conventional chemotherapy(24 months)
研究者
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