NCT00678730已完成早期 1 期
Pharmacogenetics of Cannabinoid Response
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Behavioral Measures
研究概览
简要总结
This study attempts to examine genetic influences on the effects of tetrahydrocannabinol (Δ9-THC), the active ingredient of marijuana, cannabis, "ganja", or "pot".
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 and 55 years (extremes included) on the day of the first dosing.
排除标准
- •Cannabis naïve individuals.
研究组 & 干预措施
1
Active Comparator
- Very low dose (0.005 mg/kg = 0.35 mg in a 70kg individual) THC, dissolved in ethanol. This dose is roughly equivalent to smoking 1/10th of a marijuana cigarette, or "joint".
- Low dose (0.025 mg/kg = 1.75 mg in a 70kg individual) THC, dissolved in ethanol. This dose is roughly equivalent to smoking 1/2 of a marijuana cigarette, or "joint".
- Medium dose (0.05 mg/kg = 3.5 mg in a 70 kg individual) THC, dissolved in ethanol. This dose is roughly equivalent to smoking 1 marijuana cigarette, or "joint".
干预措施: delta 9 tetrahydrocannabinol (Drug)
2
Placebo Comparator
small amount of ethanol, (quarter teaspoon), with no THC
干预措施: delta 9 tetrahydrocannabinol (Drug)
结局指标
主要结局
Behavioral Measures
时间窗: Baseline, +15, +25, +60, +300
次要结局
未报告次要终点
研究者
Deepak C. D'Souza
Principal Investigator
Yale University
研究点 (1)
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