Early Detection of Proprioceptive Dysfunction in Degenerative Cervical Myelopathy by Proprioceptive Functional Analysis in Activities of Daily Living
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Modified Japanese Orthopaedics Association Scoring System for Cervical Myelopathy (mJOA)
研究概览
简要总结
Proprioceptive deficits in degenerative cervical myelopathy (DCM) is a progressive neurological deficits in somatosensory and motor function which affects the body balance and motor control. DCM usually presents with body incoordination, hand clumsiness and gait disturbance associated with proprioceptive dysfunction that hinders the physical performance and functions. In this study, a non-invasive assessment protocol on proprioception will be developed for detecting subtle proprioceptive deficits at the early stage of disease through simple Physical Performance Tests for population older than 45. By adopting the physical performance tests as the diagnostic predictors of DCM, we aim to avoid the development of devastating consequences and disabilities.
详细描述
DCM is a chronic insidious disease, one of the most disabling orthopaedic conditions, which involves compression of the spinal cord by the surrounding structures in cervical spinal region. It characterizes with progressive neurological deficits in body coordination, hand clumsiness and gait disturbance as the preliminary symptom which may cause by proprioceptive dysfunction .
Physical performance and function hinder patients' hand clumsiness, gait disturbance and body imbalance. The incoordination between body, upper limbs and lower limbs will be resulted from proprioceptive deficits caused by spinal cord compression. By adopting the Proprioceptive Functional Analysis System (PFAS), proprioceptive deficits over the core body joints and peripheral joints could be tested during Activity of Daily Living (ADL) with reference to normal subjects' performance. All subjects will be tested by the PFAS and Physical Performance Tests.
The idea of regional proprioceptive deficit will be incorporated in the assessment protocol for DCM to facilitates a breakthrough from the traditional DCM functional evaluation.
In developing a non-invasive assessment protocol to assess proprioceptive deficit, we aim to detect subtle proprioceptive deficit from the tests, especially at the very early stage of disease. We target to demonstrate the validity of Physical Performance Tests are evenly high as that of the advanced technology, PFAS.
Consequently, by adopting the valid Physical Performance Tests in health screening scheme for population older than 45 within the community can serve as an early diagnostic parameter of DCM and avoid delayed treatment leading to devastating consequences and disabilities.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 50 or above
- •With radiological evidence of degenerative cervical myelopathy, both symptomatic and asymptomatic
- •Nurick grade less than 3
排除标准
- •Non-Chinese ethnicity
- •Aged under 50
- •without any radiological proof of cervical myelopathy
- •Active problems of tuberculosis spine, lumbar spinal diseases, and other problems causing pain or deformities over the limbs that may affect their balance and movement
- •Presents with extra-pyramidal or other disorders involving the cerebellum or frontal lobe of the cerebrum leading to poor balance and gait disturbance
- •Previous spinal operation with residual disturbance in balance or gait
- •Non-communicable patients with insufficient cognitive ability to express their symptoms clearly
- •Non-walker
- •Blind or deaf
结局指标
主要结局
Modified Japanese Orthopaedics Association Scoring System for Cervical Myelopathy (mJOA)
时间窗: 15 years
mJOA is a self-reported functional questionnaire on disease severity through assessing 4 domains: 1. Upper Limb Function 2. Lower Limb Function 3. Sensory Function 4. Bladder Function mJOA has a total score of 17 and it categories DCM patient into different severity as below: 1. Mild \>= 15 2. Moderate = 12-14 3. Severe \< 12
次要结局
- Proprioceptive Deficits - Time Limited Test(15 years)
- Proprioceptive Deficits - Speed Test(15 years)
