Towards an individualized treatment of patients with disorders of aggression regulation; endophenotypes of aggressive behavior. - Endophenotypes of Aggressive Behavior

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 154 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•- Age 18-55 years
•- Men and women
•- Outpatient
•- Meeting DSM-IV criteria for antisocial personality disorder, borderline personality disorder or the integrated research criteria for Intermittent Explosive Disorder (IED-IR):
•- Recurrent incidents of aggression manifest as either;
•Verbal or physical aggression towards other people, animals, or property occurring twice weekly
•on average for one month, or
•- Three episodes involving physical assault against other people or destruction of property over one-year period
•- The degree of aggressiveness expressed is grossly out of proportion to the provocation or any precipitating psychosocial stressors
•- The aggressive behavior is generally not premeditated (e.g., is impulsive) and is not committed in order to achieve some tangible objective (e.g., money, power, intimidation, etc.)
•- The aggressive behavior causes either marked distress in the individual or impairment in occupational or interpersonal functioning
•- The aggressive behavior is not better accounted for by another mental disorder (e.g., Major Depressive/Manic/Psychotic Disorder; ADHD); General Medical Condition (e.g., Head Trauma, Senile Dementia Alzheimer*s Type); or to the direct physiological effects of a substance
•- Score on Overt Aggression Scale-Modified for Outpatient Use (MOAS) of >= 15 and/or a score of >= 5 on the Social Dysfunction Aggression Scale (SDAS)

发起方

niversitair Medisch Centrum Sint Radboud