Role of Procalcitonin (PCT) for the Diagnosis of Sepsis in Ascitic Cirrhotic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 试验地点
- 1
研究概览
简要总结
Infections are frequent life-threatening events in patients with cirrhosis, occurring at least in 35% of hospitalized patients and accounting for 20% of inpatients death. Among cirrhotics, ascitic patients have the highest risk of death for sepsis. At the admission, no clear-cut clinical and biochemical features are helpful in diagnosing and prognostically stratifying those patients with sepsis. Procalcitonin (PCT)is a breakthrough marker presenting high sensibility and specificity in diagnosing bacterial infections in different clinical settings. The purpose of this study is to evaluate PCT as a diagnostic and prognostic tool for sepsis in hospitalized cirrhotic patients with ascitic decompensation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •liver cirrhosis regardless of aetiology
- •clinically relevant ascitic decompensation at time of hospital admission
排除标准
- •high haematic ascites
- •ongoing antimicrobial therapy or stopped less than 7 days before admission
- •last hospital discharge within 7 days
- •surgery or trauma within 30 days from enrolment
- •hepatocellular carcinoma out of Milan criteria
- •extra hepatic malignancies
- •immunodeficiency syndrome
- •pregnancy
研究者
Prof. Facchinetti Fabio
PRS Admin
University of Modena and Reggio Emilia