Innovative research on the pathogenesis of myasthenia gravis in traditional Chinese medicine (N-of-1)

The First Affiliated Hospital of Guangzhou University of Chinese Medicine0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

暂无简介。

•1) Patients aged between 18 to 65 years;
•2) Patients diagnosed with MG based on The Chinese guidelines for the diagnosis and treatment of myasthenia gravis (2020): patients with typical clinical features of MG (fluctuating myasthenia) excluded from other diseases and meeting any of the following three points, including pharmacological examination, electrophysiological characteristics or serum antibody detection;
•3) Patients attached to the spleen-stomach deficiency syndrome or spleen-kidney deficiency syndrome will be enrolled which is based on The guidelines for clinical diagnosis and treatment of internal medicine of traditional Chinese Medicine: myasthenia gravis (2020);
•4) Patients identified as class II or III according to myasthenia gravis foundation of America (MGFA) clinical classification and are in the stable stage of MG at least 3 months;
•5) Patients with Quantitative Myasthenia Gravis (QMG) score more than 6;
•6) Patients treated with glucocorticoid administration should not take more than 15mg prednisone (or an equivalent dose of other glucocorticoids) per day.

•1) Female patients who are pregnant or lactating or have a pregnancy plan during the trial;
•2) Patients with other autoimmune diseases (e.g., polymyositis, multiple sclerosis, rheumatoid arthritis) that may impact the assessment and treatment;
•3) Patients with severe heart, kidney, liver, lung, hematological system, infectious diseases or cancer;
•4) Patients with neuropsychiatric disorders that cannot cooperate;
•5) Patients received plasma exchange, glucocorticoid or gamma-globin pulse therapy within 3 months;
•6) Patients received thymectomy within half a year;
•8) Patients participating in other trials;
•9) Patients consumed antibiotics, probiotics or anti-acids during the previous two months.

发起方

The First Affiliated Hospital of Guangzhou University of Chinese Medicine