Effect of 8 Weeks of Resistance Training With Blood Flow Restriction on Muscle Strength, Clinical Parameters, Biochemical Biomarkers, and Perceived Exertion in Adults With Obesity
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- HDL cholesterol
研究概览
简要总结
To analyze the effect of 8 weeks of resistance training with blood flow restriction on muscle strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity.
详细描述
Resistance training has been demonstrated to be an effective intervention for improving muscular strength and metabolic profile. According to the available evidence, a moderate-to-high intensity level (60-90% of one-repetition maximum [1RM]) is required to achieve optimal outcomes in healthy adults.
Blood flow restriction (BFR) training, in turn, has emerged as an innovative strategy that promotes gains comparable or similar to those achieved with moderate-to-high intensity resistance training. It has been proposed as an efficient and safe training alternative in both clinical and non-clinical settings . Current findings identify BFR as a promising, versatile, accessible, and particularly useful tool when moderate-to-high intensity resistance training must be limited or contraindicated.
Therefore, the present study aims to evaluate the effects of 8 weeks of resistance training combined with blood flow restriction on muscular strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity, providing evidence regarding a potentially safe and effective intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 to 40
- •Both genders
- •BMI ≥ 30 kg/m^2 and < 40 kg/m^2
- •Signed informed consent form
排除标准
- •Participants who smoke
- •Personal and family history of vascular disease or deep vein thrombosis
- •Clinical diagnosis of hypothyroidism
- •Clinical diagnosis of type 1 diabetes mellitus
- •Clinical diagnosis of type 2 diabetes mellitus
- •Clinical diagnosis of grade 3 obesity
- •Clinical diagnosis of hypertension
- •Clinical diagnosis of acute myocardial infarction or angina pectoris
- •Use of nitrates and calcium channel blockers within 4 days prior to the start of the study
- •Use of anticoagulants
- •Use of beta-blockers or hypoglycemic agents within 7 days prior to the intervention
- •Pregnant women
- •Breastfeeding women
- •Men consuming more than 40 g of alcohol per day or women consuming more than 20 g per day
- •Postural and biomechanical disorders (knee, foot, and spine)
研究组 & 干预措施
BFR group
This group will train for 8 weeks
干预措施: Intervention (Other)
Control group
This group will train for 8 weeks
干预措施: Intervention (Other)
结局指标
主要结局
HDL cholesterol
时间窗: Baseline and after 8 weeks
HDL cholesterol (mg/dl): Changes from baseline to 8 weeks of intervention
LDL cholesterol
时间窗: Baseline and after 8 weeks
LDL cholesterol (mg/dl): Changes from baseline to 8 weeks of intervention
C-reactive protein (CRP)
时间窗: Baseline and after 8 weeks
CRP (mg/dl): Changes from baseline to 8 weeks of intervention
Interleukin-6 (IL-6)
时间窗: Baseline and after 8 weeks
IL-6 (pg/mL):Change from baseline to 8 weeks of intervention.
Tumor Necrosis Factor Alpha (TNF-α)
时间窗: Baseline and after 8 weeks
TNF-α (pg/mL): Change from baseline to 8 weeks of intervention
Weight
时间窗: Baseline and after 8 weeks
Weight (kg): Changes in weight from baseline to 8 weeks of intervention.
Height
时间窗: Baseline and after 8 weeks
Height (cm): Changes in height from baseline to 8 weeks of intervention
Muscle strength
时间窗: Baseline and after 8 weeks
Muscle strength (kg): Change from baseline to 8 weeks of intervention. Muscle strength will be assessed using dynamometry
Dynamic muscle strength
时间窗: Baseline and after 8 weeks
Dynamic muscle strength (kg): Change from baseline to 8 weeks of intervention.
Arm circumference
时间窗: Baseline and after 8 weeks
Arm circumference (cm): Change from baseline to 8 weeks of intervention. Measurements will be obtained using a non-elastic measuring tape in accordance with the International Society for the Advancement of Kinanthropometry (ISAK) protocol
Thigh circumference
时间窗: Baseline and after 8 weeks
Thigh circumference (cm): Change from baseline to 8 weeks of intervention. Measurements will be obtained using a non-elastic measuring tape in accordance with the International Society for the Advancement of Kinanthropometry (ISAK) protocol
Total cholesterol
时间窗: Baseline and after 8 weeks
Total cholesterol (mg/dl): Changes from baseline to 8 weeks of intervention
Maximum oxygen uptake (VO₂max)
时间窗: Baseline and after 8 weeks
VO₂max (ml/min/kg): Change from Baseline at 8 weeks, measured using a submaximal exercise test based on the Åstrand-Ryhming protocol
Systolic blood pressure (SBP)
时间窗: Baseline and after 8 weeks
SBP (mmHg): Changes from baseline to 8 weeks of intervention
Diastolic blood pressure (DBP)
时间窗: Baseline and after 8 weeks
DBP (mmHg): Changes from baseline to 8 weeks of intervention
Heart rate
时间窗: Baseline and after 8 weeks
Heart rate (bpm): Change from baseline to 8 weeks of intervention.
Glucose
时间窗: Baseline and after 8 weeks
Glucose (mg/dl): Changes from baseline to 8 weeks of intervention
Triglycerides
时间窗: Baseline and after 8 weeks
Triglycerides (mg/dl): Changes from baseline to 8 weeks of intervention
Body mass index (BMI)
时间窗: Baseline and after 8 weeks
BMI (kg/m\^2): Change from Baseline at 8 weeks, calculated by: weight (kg)/ height (m\^2).
Body fat percentage
时间窗: Baseline and after 8 weeks
Body fat percentage (%): Changes in body fat assessed by bioelectrical impedance analysis (BIA)
Muscle mass percentage
时间窗: Baseline and after 8 weeks
Muscle mass percentage (%): Changes in muscle mass measured using bioelectrical impedance analysis (BIA)
Perceived Exertion
时间窗: Baseline and after 8 weeks
Perceived exertion will be assessed using the Rating of Perceived Exertion Scale (RPE)
Exercise enjoyment
时间窗: Baseline and after 8 weeks
Exercise enjoyment will be assessed using the validated Physical Activity Enjoyment Scale Questionnaire (PACES)
次要结局
未报告次要终点
研究者
José Manuel Pérez Casillas
Principal Investigator
Centro Universitario de Tlajomulco, Universidad de Guadalajara