A study on Osteoarthritis of knee evaluating the effects of Biologics with Bio-mechanical correction for regeneration of cartilage.

JAWAHARLAL NEHRU MEDICAL COLLEGE1 个研究点分布在 1 个国家目标入组 30 人开始时间: 2023年7月20日最近更新: 2023年12月7日

试验速览

阶段: 3 期
状态: 尚未招募
发起方: JAWAHARLAL NEHRU MEDICAL COLLEGE
入组人数: 30
试验地点: 1
主要终点: Biomechanical correction with biologics (PRP) can lead to cartilage regeneration

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Osteoarthritis is the most common cause of disability in the older population.It is due to the wear of the cartilage. Direct infiltrate of Platelet rich plasma in the normal or near normal cartilage should trigger cartilage regeneration leading to filling up of the cartilage defect/improving the quality of remaining cartilage.Proximal fibular osteotomy should deload the medial compartment and further assist the prevention of cartilage regeneration by indirect prevention.

研究设计

研究类型: Interventional
分配方式: Not Applicable
盲法: Not Applicable

入排标准

年龄范围: 35.00 Year(s) 至 65.00 Year(s)（—）
性别: All

入选标准

•1- Patients OA knee.
•Grade II and III 2- Radiological evidence of medial compartment involvement. 3- Primary OA knee patients. 4- Patients who are willing to take part in study after informed consent.

排除标准

•1-Post traumatic knee stifness 2-History of infective joint disease.
•3-Patients with history of previous surgeries of knee.
•4-Co-morbid/pathology of ipsilateral hip/foot joint pathology 5-Any other defect of ipsilateral limb like shortening etc.

结局指标

主要结局

Biomechanical correction with biologics (PRP) can lead to cartilage regeneration

时间窗: at 0 , 3 , 12 , 24 weeks and 9 months

次要结局

Correction of varus deformity(Correction of varus deformity at 0, 6 , 12 , 24 weeks and 6 and 9 months)

研究者

发起方

JAWAHARLAL NEHRU MEDICAL COLLEGE

申办方类型

Private medical college

研究点 (1)

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