Dietary Sulfur Amino Acid Restriction, Energy Metabolism and Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 2
- 主要终点
- Changes in body weight
研究概览
简要总结
The primary objective of the trial is to establish the effects of dietary sulfur amino acid (SAA) restriction on body weight, body composition and energy expenditure in humans.
详细描述
Dietary SAA restriction is an established model for increasing lifespan and improving metabolic health in animal studies. Data from human studies are limited.
In this study the investigators will perform an 8-week dietary intervention with SAA restriction to characterise the effects on several parameters related to metabolic health including body weight, body composition, energy expenditure, lipid profile and gene expression profiles in adipose tissue. The aim is to translate findings from previous animal experiments to humans
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy participants with overweight and obesity (BMI 27-35 kg/m2)
- •Waist circumference > 80 cm for women and > 94 cm for men
排除标准
- •Presence of chronic disease
- •Established co-morbidities
- •Already on a vegan diet or have been the last month
- •Pregnancy
- •Breastfeeding the last 3 months
- •Unstable body weight the last 3 months
- •High intensity training > 3 times weekly
结局指标
主要结局
Changes in body weight
时间窗: At baseline, 4 and 8 weeks
Kilograms
次要结局
- Changes in resting energy expenditure(At baseline, 4 and 8 weeks)
- Changes in plasma concentrations of SAA and related intermediates and compounds(At baseline, 4 and 8 weeks)
- Changes in concentrations of plasma lipid profile(At baseline, 4 and 8 weeks)
- Changes in plasma concentrations of adipokines and appetite hormones(At baseline, 4 and 8 weeks)
- Changes in fibroblast growth factor 21 (FGF21)(At baseline, 4 and 8 weeks)
- Changes in gut microbiota(At baseline, 4 and 8 weeks)
- Changes in body composition(At baseline, 4 and 8 weeks)
- Changes in substrate oxidation(At baseline, 4 and 8 weeks)
- Changes in urine concentrations of SAA and related intermediates and compounds(At baseline, 4 and 8 weeks)
- Changes in plasma makers of insulin sensitivity(At baseline, 4 and 8 weeks)
- Changes in biomarkers related to obesity and energy metabolism(At baseline, 4 and 8 weeks)
- Changes in gene expression(At baseline, 4 and 8 weeks)
- Vitamin status(At baseline, 4 and 8 weeks)
- Changes in short chain fatty acids(At baseline, 4 and 8 weeks)
- Nitrogen balance(At baseline, 4 and 8 weeks)
研究者
Kathrine Vinknes
Researcher
University of Oslo