Study on Early Warning Model of Susceptibility and High-risk Population of Cervical Cancer Related to HPV
试验速览
- 阶段
- 不适用
- 入组人数
- 20,000
- 试验地点
- 1
- 主要终点
- Significant loci of genetic variation
研究概览
简要总结
Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to establish an early warning model for a high-risk population of cervical cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 25 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •(1) Case group a) Aged 25-75 years. b) Han nationality. c) Patients with cervical cancer or cervical precancerous lesions above CIN2 diagnosed by biopsy or postoperative pathological diagnosis.
- •(2) Control group: a) Aged 25-75 years. b) Han nationality. c) No family history of cervical cancer or precancerous lesions. d) The results of TCT examination showed no abnormality.
排除标准
- •(1) suffering from other neoplastic diseases.
- •(2) pregnant women.
- •(3) those with a history of bone marrow transplantation.
结局指标
主要结局
Significant loci of genetic variation
时间窗: 2
The impact of genetic variance on predisposition to cervical cancer
次要结局
未报告次要终点
研究者
Ding Ma
Director of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College
Huazhong University of Science and Technology