Assessment of Nutrient Profile, Nutritional Status, Development and Severity of Children With Autistic Spectrum Disorder in Comparison With Typically Developing Children in Addis Ababa, Ethiopia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Carbohydrate intake using three days food diary questioner
研究概览
简要总结
The study conducts a case control analysis of the nutritional status and intake of autistic spectrum disorder diagnosed children as compared to typically developing children in Addis Ababa, Ethiopia. It included analysis of anthropometric measurements, three days food diary food intake, urinary iodine analysis, childhood autism rating scale diagnosis, food frequency and eating behavior questioner and proximate analysis of one day major meals of selected subjects.
详细描述
Sample population was Addis Ababa city in which subjects were selected from one of the two autism centers in the country. Random sampling method was applied to select subject from the total enrolled children in the center using Ryan 2013 sample size calculation formula.
Subjects already diagnose with autistic spectrum disorder that didn't have any other chronic disease that affect diet and nutrition were included in the study. Subjects were selected randomly from each grade level in the center. They were registered and taken for data collection. Sample and Data was collected with the help of each child's center caregiver and parent. Childhood autism rating scale diagnosis, eating behavior analysis were analyzed for the ASD and anthropometric indices Z scores, urine iodine concentration, three days food diary analysis, major meals proximate analysis, food frequency and dietary diversity was assessed and compared to typically developing children in Addis Ababa.
Data entry and analysis was conducted using Emergency Nutrition Assessment software, Microsoft excel and Statistical Package for the Social Sciences software.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 4 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children already diagnosed with ASD
- •school aged children (4-18 years old)
排除标准
- •children with chronic illnesses ( such as cancer..)
- •children taking heavy medications that may affect diet and nutrition
结局指标
主要结局
Carbohydrate intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of carbohydrate in gm/day
Vitamin A intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of vitamin A in mg/day
Autism symptom severity of children using Childhood Autism rating Scale diagnosis
时间窗: 2 days
Childhood autism rating scale assessed by total raw scores by age. for age 0-12, scores of 15-29.5 indicate limited behavior related to autism, score of 30-36.5 indicate mild to moderate level of behavior related to autism, score 37-60 indicate sever level behavior related to autism. for age 13 years and older, 15-27.5 indicate limited behavior related to autism, score of 28-34.5 indicate mild to moderate level of behavior related to autism, score 35-60 indicate sever level behavior related to autism.
Weight for age z-scores
时间窗: 1 day
weight and age will be combined to report weight for age z-scores in kg for age in months
Calcium intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of calcium in mg/day
Vitamin B2 intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of vitamin B2 in mg/day
Urine iodine concentration of children
时间窗: 2 month
Urine iodine concentration of children in µg /L
Height for age z-scores
时间窗: 1 day
Height and age will be combined to report height for age z-scores in centimeter for age in months
Zinc intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of zinc in mg/day
Niacin intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of niacin in mg/day
Body Mass Index for age z-scores
时间窗: 1 day
Body Mass Index and age will be combined to report Body mass index for age z-score in Kg/m2 for age in months
Energy intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of energy in kcal/day
Protein intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of protein in gm/day
Lipid intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of lipid in gm/day
Vitamin C intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of vitamin C in mg/day
Iron intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of Iron in mg/day
Thiamine intake using three days food diary questioner
时间窗: 5 days
Three days food diary questioner will be used to report intake of Thiamine in mg/day
次要结局
- protein intake using proximate analysis of one day major meals(2 months)
- frequency of food group consumption using food frequency questioner(5 days)
- frequency of food allergic reactions(5 days)
- energy intake using proximate analysis of one day major meals(2 months)
- Ash intake using proximate analysis of one day major meals(2 months)
- dietary diversity score of children using three days food diary(5 days)
- frequency of food refusal in children using a questioner(5 days)
- Lipid intake using proximate analysis of one day major meals(2 months)
- Carbohydrate intake using proximate analysis of one day major meals(1 week)
- frequency of sensitivity to food(5 days)
- frequency of gastrointestinal symptoms(5 days)
研究者
Feven yirgu Tamire
Principal Investigator
Addis Ababa University