Impact of Vitamin C Supplementation on the Hospital Outcomes in Children Undergoing Corrective Heart Surgery for Congenital Heart Diseases
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 20
- 主要终点
- The improvemnents of Ejection Fraction between the two groups
研究概览
简要总结
Vitamin C will be given before admission in the immediate preoperative preceding 7 days (the dose 30 -45 mg per day ) in oral drops preparations
Inflammatory markers including CRP , TLC ,PNI , GPS NLR will be checked on admission and on discharge and compared between cases and controls Hospital length stay will also be compared between the two groups
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- — 至 7 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children in the first two years who will be for corrective surgery for heart diseases congenital heart diseases
- •Pediatric patients whose parents or caregivers agree to be enrolled in the study.
- •Risk Adjustment for Congenital Heart Surgery -1 (RACHS-1) for Evaluation of Mortality in Children Undergoing Cardiac Surgery : the first two categories (Thiagarajan and C. Laussen 2015)
排除标准
- •Pediatric patients with associated comorbid conditions.
研究组 & 干预措施
The control group
A placebo will be given before admission in the immediate preoperative preceding 7 days (the dose 30 -45 mg per day ) in oral drops preparations
Inflammatory markers including CRP , TLC ,PNI , GPS NLR will be checked on admission and on discharge and compared between cases and controls Hospital length stay will also be compared between the two groups
干预措施: Placebo (Other)
Interventional
Vitamin C will be given before admission in the immediate preoperative preceding 7 days (the dose 30 -45 mg per day ) in oral drops preparations
Inflammatory markers including CRP , TLC ,PNI , GPS NLR will be checked on admission and on discharge and compared between cases and controls Hospital length stay will also be compared between the two groups
干预措施: Vitamin C (Other)
结局指标
主要结局
The improvemnents of Ejection Fraction between the two groups
时间窗: 7-10 days
Each group wil be evaluated for the eiection fraction before and after the operation and the improvement will be compared
次要结局
未报告次要终点
研究者
Hoda Atef Abdelsattar Ibrahim
Hoda Atef Abdelsattar Ibrahim
Cairo University