NCT06079151Unknown不适用
Physiological Evaluation of the Hemodynamic Effects of Nasal High Flow in Patients Being Explored by Right Heart Catheterisation and Echocardiography for Suspected or Followed Precapillary Pulmonary Hypertension
ADIR Association2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2024年2月13日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Cardiac output
研究概览
简要总结
In this study, the investigators aim to describe the hemodynamic consequences of nasal high-flow measured during right heart catheterization and echocardiography. The research hypothesis is that nasal high-flow would increase cardiac output in patients with pulmonary hypertension. The concomitant echocardiography will allow to describe its sensibility to detect cardiovascular consequences of nasal high-flow.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- patient addressed for right heart catheterization for pulmonary hypertension suspicion or follow-up.
排除标准
- •necessity of FiO2 >21% during right heart catheterization
- •intracardiac shunt
- •grade 4 tricuspid insufficiency
- •complete arrhythmia due to atrial fibrillation
- •Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception
- •protected adult patient (tutorship or curatorship)
- •patient deprived of liberty by court or administrative decision
- •refusal of patient participation or consent
- •patient for whom the measurement of pulmonary arterial pressures during right heart catheterization is impossible
- •patient for whom, during the etiological assessment of pulmonary hypertension, the diagnosis of precapillary pulmonary hypertension cannot be confirmed and classified in groups 1, 3 or 4.
结局指标
主要结局
Cardiac output
时间窗: During the intervention, at isotime
Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min
次要结局
- pulse oxygen saturation(During the intervention, at isotime)
- capillary wedge pressure measured by catheterization and echocardiography.(During the intervention, at isotime)
- cardiac output measured by catheterization and echocardiography.(During the intervention, at isotime)
- Consequences of nasal high-flow 50 and 30 L/min FiO2 21% on echocardiographic parameters.(During the intervention, at isotime)
- systolic pulmonary arterial pressure measured by catheterization and echocardiography.(During the intervention, at isotime)
- right atrial pressure measured by catheterization and echocardiography.(During the intervention, at isotime)
- respiratory rate(During the intervention, at isotime)
- systolic ejection volume(During the intervention, at isotime)
- cardiac output(During the intervention, at isotime)
- Right atrial pressure(During the intervention, at isotime)
- systolic pulmonary arterial pressure(During the intervention, at isotime)
- diastolic pulmonary arterial pressure(During the intervention, at isotime)
- mean pulmonary arterial pressure(During the intervention, at isotime)
- capillary wedge pressure(During the intervention, at isotime)
- pulmonary vascular resistance(During the intervention, at isotime)
- central venous oxygen saturation(During the intervention, at isotime)
- heart rate(During the intervention, at isotime)
- systolic arterial pressure(During the intervention, at isotime)
- diastolic arterial pressure(During the intervention, at isotime)
- mean arterial pressure(During the intervention, at isotime)
研究者
研究点 (2)
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