Compromised Microcirculation in Women With Polycystic Ovary Syndrome
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Skin blood flow and cutaneous vascular conductance
研究概览
简要总结
The scientific aims of the study are to determine how peripheral microcirculatory responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local heating and to determine the mechanism for testosterone effects on peripheral microcirculatory responsiveness in women with PCOS.
详细描述
In these studies, we propose to use the skin as a relatively non-invasive model to examine cardiovascular and endothelial function in obese women with and without PCOS. Data have indicated an important role for testosterone in influencing the peripheral microcirculation. While testosterone can lead to vasodilation in the peripheral microcirculation in both men and in women without PCOS, testosterone appears to induce vasoconstriction in women with PCOS. The differential response between women with and without PCOS, and between men and women may be the result of differential ET-1 actions in the vessel, and regulated by the receptor subtype is involved in these actions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Obese women (18-35) years with and without PCOS
排除标准
- •Conditions that would preclude safe use of hormones
研究组 & 干预措施
2
GnRH with Testosterone
干预措施: methyl testosterone (Drug)
1
GNRH antagonist alone
干预措施: ganirelix acetate (Drug)
结局指标
主要结局
Skin blood flow and cutaneous vascular conductance
时间窗: 6 non consecutive days
次要结局
未报告次要终点