Imaging and Understanding BOS in Lung Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Analysis of MRI imaging to detect BOS compared to biopsy
研究概览
简要总结
This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years.
详细描述
This study is a prospective, non-randomized, longitudinal, observational study that will recruit about 5 lung transplant patients per year for 3 years. We will follow these patients at 6 months and 1 year with Hyperpolarized Helium-3 Magnetic Resonance Imaging and image guided bronchial biopsies to detect early BOS and to better understand BO disease progression. The biopsies will provide future research for rapid determination of cellular and molecular mechanisms that lead to BOS and to facilitate identification and validation of translatable pharmaceutical targets.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Year 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Lung Transplantation within the last 10 years or being assessed for possible lung transplantation.
- •Male or female
- •0 to 25 years of age.
排除标准
- •Standard MRI exclusion criteria as set forth by the CCHMC Division of Radiology
- •Inability to perform 10 second breath hold for 3He MRI scan
- •Bleeding disorders
研究组 & 干预措施
Post transplant subjects
Hyperpolarized Helium-3 MRI. Subjects who have had or are scheduled to have a lung transplant
干预措施: Hyperpolarized Helium-3 MRI (Drug)
结局指标
主要结局
Analysis of MRI imaging to detect BOS compared to biopsy
时间窗: 3 years
Analysis of MRI imaging to detect BOS compared to biopsy
次要结局
未报告次要终点