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Influence of individual genetic determination of the BDNF Val66Met polymorphism on plasticity-related sensorimotor recovery after ischemic stroke

eurologischen Klinik und PoliklinikBG-Universitätsklinikum BergmannsheilRuhr-Universität Bochum0 个研究点目标入组 75 人开始时间: 2012年1月31日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Aged between 40 and 70 years;
•Right-handedness before the infarction according to the Einburgh Inventory of Handedness;
•Ischemic infarct (cortical/subcortical) in the coverage area of the middle cerebral artery, according to cranial CT or MRI;
•Unilateral impairment of sensorimotor performance of upper extremities, i.e. an easy-to-moderate hemiparesis: Grade 3-5 according to MRC;
•Ability to conduct subtest 1 and 2 of the Jebsen-Taylor Hand Function Test

•Lack of knowledge of German language (subjective assessment of the experimenter);
•Cognitive impairment in accordance DemTect (score <10; without the task 2 convert numbers);
•Taking CNS-active drugs of any kind;
•Residual symptoms of previous neurological diseases (including stroke, lesions, polyneuropathy);
•Psychiatric disorders that might influence therapy;
•Pacemaker (safety criterion for the electrical stimulation);
•Increased muscle tone in the proximal or distal arm muscles (> 1 + according to MAS);
•Excessive hand tremor (= 1 in subitem 20; 21 of the UPDRS);
•Absolute loss of sensorimotor performance of upper extremities (hemi- or paraplegia) and severe paresis (MRC grade 0-2; inability to perform subtest 1 and 2 of the Jebsen-Taylor Hand Function Test);
•Aphasia, preventing an informed consent;
•Perception threshold of electric stimulation of 20 mA / channel

发起方

eurologischen Klinik und PoliklinikBG-Universitätsklinikum BergmannsheilRuhr-Universität Bochum